As a leading Raleigh OBGYN practice, our commitment is to provide every woman with the knowledge and care she needs to protect her health. One of the most serious health concerns we address is ovarian cancer.
Ovarian cancer is often called the “silent killer” because its symptoms are frequently vague, nonspecific, and easily mistaken for less serious conditions, such as irritable bowel syndrome (IBS), or even natural changes that occur during aging or perimenopause. This difficulty in early detection is why understanding the diagnostic process is so crucial. Early detection can dramatically improve outcomes, making it vital for every woman to be aware of the symptoms and the steps involved in diagnosis.
This comprehensive guide will walk you through the entire process of how ovarian cancer is diagnosed, from initial symptom recognition and first office visits to advanced imaging and the definitive diagnosis provided by a biopsy.
Step 1: Recognizing and Reporting Symptoms
The first and most important step in the diagnostic process begins with you, the patient. While there is currently no routine, effective screening test for ovarian cancer in average-risk women, recognizing persistent, troubling symptoms is the key to prompt investigation.
The most common symptoms associated with ovarian cancer are often described as persistent and new, meaning they occur frequently (more than 12 times a month) and represent a distinct change from what is normal for you.
Key Symptoms to Discuss with Your OBGYN:
- Bloating: Persistent abdominal swelling or bloating that does not go away.
- Pelvic or Abdominal Pain: Pain or discomfort in the lower abdomen or pelvis.
- Difficulty Eating or Feeling Full Quickly (Early Satiety): Feeling full after eating only a small amount of food.
- Urinary Symptoms: Needing to urinate more frequently or having an urgent need to urinate.
Other Potential Symptoms Include:
- Fatigue (extreme tiredness)
- Back pain
- Upset stomach or indigestion
- Constipation or other changes in bowel habits
- Pain during sexual intercourse
- Unexplained weight loss
- Abnormal vaginal bleeding, especially postmenopause
If you experience these symptoms more than 12 times a month for a few weeks, scheduling an appointment with your Raleigh OBGYN is crucial. While less serious conditions often cause these symptoms, a thorough evaluation is necessary to rule out ovarian cancer.
Step 2: The Initial OBGYN Evaluation
When you visit our office with concerning symptoms, your doctor will begin with a thorough evaluation, which typically includes:
A. Comprehensive Personal and Family History
Your doctor will ask detailed questions about your symptoms, including when they started, how often they occur, and their severity. They will also review your personal medical history, including menstrual cycles, pregnancies, and past surgeries.
Crucially, they will take a detailed family history. Factors that can increase your risk of ovarian cancer include:
- A personal or family history of breast, colon, or ovarian cancer.
- Known inherited gene mutations, such as BRCA1 or BRCA2, or those associated with Lynch syndrome.
- Endometriosis.
If you are found to be at a high risk, your doctor may recommend more intensive surveillance, including regular transvaginal ultrasounds and CA-125 blood tests, though these are not used for general population screening.
B. The Physical and Pelvic Exam
A physical exam will be performed to check for any signs of disease, such as unexplained weight loss or a buildup of fluid in the abdomen (called ascites).
A pelvic exam is a standard part of the checkup. During this exam, your doctor carefully checks the size, shape, and consistency of your ovaries and uterus. While advanced ovarian tumors may sometimes be felt during a manual exam, most early ovarian tumors are too small to be detected this way. It is important to remember that a routine Pap test screens for cervical cancer and does not screen for ovarian cancer.
Step 3: Diagnostic Testing
If your symptoms, physical exam, or risk factors raise suspicion for ovarian cancer, your OBGYN will order specific diagnostic tests. These tests are usually used in combination.
A. Transvaginal Ultrasound (TVUS)
The transvaginal ultrasound is one of the most common first-line imaging tests used when an ovarian issue is suspected.
How it works: A small ultrasound probe is gently inserted into the vagina. This probe uses sound waves to create detailed images of the uterus, fallopian tubes, and ovaries on a screen.
What it shows: The TVUS helps the doctor visualize the ovaries. It can detect the presence of an ovarian mass (tumor or cyst) and help determine its characteristics:
- Size: How large the mass is.
- Structure: Whether it is a simple, fluid-filled cyst, a solid tumor, or a complex mass with both fluid and solid components.
- Morphology: Whether there are worrisome features like solid areas or abnormal blood flow.
While a TVUS is excellent at finding ovarian masses, it cannot definitively determine if a mass is cancerous or benign. Most masses found are, in fact, benign cysts. However, features suggestive of malignancy will prompt further investigation.
B. The CA-125 Blood Test
CA-125 is a protein (a tumor marker) found in the blood that is often elevated in women with epithelial ovarian cancer.
How it works: A blood sample is taken and analyzed to measure the level of the CA-125 protein. Levels below 35 units per milliliter (U/mL) are generally considered normal.
What it shows and its limitations:
- Elevated Levels: High levels can suggest the presence of ovarian cancer, especially in postmenopausal women with a pelvic mass.
- False Positives: The level of CA-125 can also be elevated by many common, benign conditions, including menstruation, endometriosis, uterine fibroids, pelvic inflammatory disease (PID), and even pregnancy. Therefore, a high CA-125 level alone does not diagnose ovarian cancer.
- False Negatives: Conversely, not all women with ovarian cancer have a high CA-125 level, particularly in the early stages (up to 50% of early-stage cancers do not show an elevation).
Due to these limitations, the CA-125 test is primarily used in conjunction with imaging tests to help assess a suspicious mass, and it is also widely used to monitor treatment effectiveness or check for recurrence after a cancer diagnosis.
C. Other Imaging Tests
If the TVUS and CA-125 test results are highly concerning, or if your doctor needs to check for the spread of disease, additional imaging tests may be ordered:
- CT Scan (Computed Tomography): This X-ray test creates detailed cross-sectional images of the entire body. It is often used to visualize larger tumors, check for signs of cancer spread to other organs (like the liver), and detect fluid buildup (ascites).
- MRI Scan (Magnetic Resonance Imaging): This uses strong magnets and radio waves to create more detailed images, and is sometimes used to evaluate a pelvic mass further or check for distant spread.
Step 4: The Definitive Diagnosis: Biopsy
The tests described above can only suggest the presence of ovarian cancer. The only way to definitively diagnose ovarian cancer and determine its specific type is through a biopsy, which involves obtaining tissue or cells for examination by a pathologist.
In the case of ovarian cancer, a biopsy is often obtained during surgery, as a needle biopsy on a suspicious ovarian mass is generally avoided due to the potential risk of spreading cancer cells if the mass is malignant.
Biopsy Procedures:
- Surgical Biopsy (Laparotomy or Laparoscopy): This is the most common method. If imaging and blood tests strongly suggest cancer, you will likely be referred to a Gynecologic Oncologist, a specialist in female reproductive cancers. The surgeon removes the suspicious mass and surrounding tissues during surgery (either a large incision or a minimally invasive laparoscopy). A pathologist immediately analyzes a sample while the patient is still in surgery (a “frozen section”). If cancer is confirmed, the surgeon proceeds with the full cancer staging and removal procedure (debulking). Seeking care from a gynecologic oncologist is strongly recommended, as studies show patients treated by these specialists often experience improved outcomes.
- Needle Biopsy (Rare): In some cases, such as when cancer has spread to another area (a metastasis), or if a patient has significant health issues that prevent immediate surgery, a radiologist may use a CT or ultrasound to guide a needle into the tumor to obtain a sample.
- Paracentesis: If there is a large amount of ascites (fluid in the abdomen), a procedure called paracentesis may be performed to draw off the fluid, which is then analyzed for cancer cells.
Conclusion
The diagnostic journey for ovarian cancer involves several critical steps, starting with your awareness of subtle but persistent symptoms. At Raleigh OBGYN, we emphasize the importance of open communication about any new or troubling physical changes.
We are here to provide comprehensive care and guide you through every step, from initial evaluation and advanced testing to referring you to the most skilled specialists, if necessary. If you have concerns about your risk factors or are experiencing any persistent symptoms mentioned, do not hesitate to schedule an appointment with us. Taking proactive steps for your health is the most important thing you can do.